Peptides

Melanotan II

Evidence: moderate_human

Mechanism of Action

Melanotan II is a synthetic cyclic analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that non-selectively agonizes melanocortin receptors MC1, MC3, MC4, and MC5. MC1R activation stimulates eumelanin synthesis through tyrosinase upregulation, producing tanning. MC3R activation in the CNS increases libido and produces erectile responses. MC4R activation suppresses appetite. The cyclic structure provides enhanced in vivo stability (half-life 1-2 hours) and increased blood-brain barrier permeability compared to linear alpha-MSH.

Dosing Protocol

Standard: Research indicates 250-500 mcg daily via subcutaneous injection during loading, reducing to 250 mcg 2-3 times weekly for maintenance.

Loading: Research indicates 250 mcg daily for 1-2 weeks until desired pigmentation is achieved.

Maintenance: Research indicates 250-500 mcg once or twice weekly to maintain pigmentation.

Administration: subcutaneousintranasal

Timing: Administer 4-6 hours before UV exposure for optimal tanning synergy. Can be taken at any time of day.

Duration: Loading phase 1-2 weeks, then maintenance as long as desired. Pigmentation fades gradually upon discontinuation.

Notes

Melanotan II carries unique risks: darkening and potential transformation of existing moles is the primary safety concern, as melanocortin-stimulated melanocyte proliferation could theoretically promote melanoma in predisposed individuals. All clients must have a full dermatological mole mapping before starting and undergo regular skin checks during use. Spontaneous erections and increased libido are common side effects (not always desired). Nausea is dose-dependent and typically resolves after loading phase. Starting at 100 mcg and titrating up reduces nausea. Banned by TGA (Australia) and many sports organizations.

Stacking

  • PT-141

Interactions

  • PT-141 (Bremelanotide) [MEDIUM] — Both activate melanocortin receptors; do not use simultaneously. Choose one or the other.
  • Photosensitizing drugs [MEDIUM] — Melanotan II enhances UV sensitivity; increased burn risk with photosensitizers.
  • Appetite suppressants [LOW] — Additive appetite suppression via MC4R activation.

Contraindications

  • History of melanoma or atypical moles
  • Active skin cancer
  • Pregnancy and breastfeeding
  • Addison's disease
  • Pheochromocytoma

Side Effects

  • Nausea (common, especially during loading)
  • Facial flushing
  • Spontaneous erections
  • Appetite suppression
  • Darkening of existing moles (monitor closely)
  • Fatigue
  • New nevus formation

Key Papers

  • 10.1038/sj.ijir.3900940
  • 10.1111/jdv.20269

Source Quality

Research-grade supplier only. NOT FDA-approved. Banned by multiple regulatory agencies. Requires UV exposure for tanning effect.

Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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