Peptides

Hexarelin

Evidence: moderate_human

Mechanism of Action

Hexarelin (Examorelin) is a synthetic hexapeptide GHS-R1a agonist and the most potent synthetic GH secretagogue by peak GH release. It stimulates GH release through both pituitary ghrelin receptors and hypothalamic pathways, with mechanisms involving regulation of GHRH and somatostatin. Hexarelin also demonstrates significant cardiac benefits through activation of cardiac GHS-R1a receptors, protecting against ischemia-reperfusion injury and reducing cardiac fibrosis via the CD36 scavenger receptor pathway.

Dosing Protocol

Standard: Research indicates 100-200 mcg administered 1-2 times daily via subcutaneous injection.

Maintenance: Research indicates 100 mcg at bedtime. Note: desensitization occurs rapidly.

Administration: subcutaneousintramuscularintranasal

Timing: On empty stomach, bedtime preferred. Avoid prolonged continuous use due to rapid desensitization.

Duration: 4-8 week cycles maximum, then 4+ week break. Hexarelin desensitizes faster than other GHRPs.

Notes

Hexarelin produces the highest peak GH release of any synthetic secretagogue but desensitizes rapidly (within 2-4 weeks of continuous use), making it unsuitable for long-term protocols. Its unique cardiac protective properties (via CD36 receptors) make it of particular interest for cardiac optimization. Best used in short bursts rather than sustained protocols. The desensitization issue limits its practical utility compared to Ipamorelin.

Stacking

  • CJC-1295 (no DAC)
  • Sermorelin

Interactions

  • Insulin [HIGH] — GH antagonizes insulin.
  • Glucocorticoids [MEDIUM] — Hexarelin raises cortisol and ACTH significantly.
  • Cardiac medications [MEDIUM] — Hexarelin has direct cardiac effects; coordinate with cardiologist.

Contraindications

  • Active cancer
  • Cardiac arrhythmias (due to direct cardiac receptor activity)
  • Cushing's syndrome
  • Pregnancy and breastfeeding

Side Effects

  • Significant cortisol elevation
  • Prolactin increase
  • Water retention
  • Joint pain
  • Rapid desensitization (unique to Hexarelin)

Key Papers

  • 10.1530/eje.0.1350421
  • 10.1124/jpet.108.149492

Source Quality

Research-grade supplier. Less commonly available through compounding pharmacies than Ipamorelin/GHRP-2.

Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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