Peptides

GHRP-6

Evidence: moderate_human

Mechanism of Action

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide that stimulates GH release through activation of the growth hormone secretagogue receptor (GHS-R1a/ghrelin receptor) on pituitary somatotrophs. It acts via dual sites — pituitary and hypothalamic — possibly involving regulatory factors beyond GHRH and somatostatin. GHRP-6 also stimulates ghrelin-mediated appetite signaling, increases cortisol and prolactin release, and has demonstrated cytoprotective properties including cardioprotection.

Dosing Protocol

Standard: Research indicates 100-300 mcg administered 1-3 times daily via subcutaneous injection.

Maintenance: Research indicates 100 mcg at bedtime.

Administration: subcutaneousintramuscular

Timing: On empty stomach, 30+ minutes before meals. Bedtime dose most important. The strong hunger effect makes pre-meal timing practical.

Duration: 8-16 week cycles.

Notes

GHRP-6 is the most potent appetite-stimulating GH secretagogue — this is either a feature or a bug depending on the client's goals. Useful for underweight clients or those needing caloric surplus for recovery, but problematic for those managing body composition. Less selective than Ipamorelin (raises cortisol and prolactin). Generally considered a second-line choice after Ipamorelin for most optimization protocols.

Stacking

  • CJC-1295 (no DAC)
  • Sermorelin

Interactions

  • Insulin [HIGH] — GH elevation antagonizes insulin.
  • Appetite suppressants [MEDIUM] — GHRP-6 causes significant hunger increase, which may counteract appetite suppressants.
  • Glucocorticoids [MEDIUM] — GHRP-6 stimulates ACTH/cortisol release; additive cortisol elevation.

Contraindications

  • Active cancer
  • Obesity (significant appetite stimulation)
  • Cushing's syndrome
  • Pregnancy and breastfeeding

Side Effects

  • Intense hunger (primary distinguishing side effect)
  • Water retention
  • Cortisol elevation
  • Prolactin elevation
  • Tingling and numbness
  • Injection site pain

Key Papers

  • 10.1016/S0091-3022(97)90158-8
  • 10.1210/en.2010-0115

Source Quality

Compounding pharmacy or research-grade supplier with COA.

Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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