Peptides
Evidence: animal_plus_anecdotal
Epitalon (Ala-Glu-Asp-Gly / AEDG) is a synthetic tetrapeptide based on the natural pineal gland peptide epithalamin. It activates telomerase by inducing expression of the catalytic subunit hTERT, resulting in telomere elongation averaging 33.3% in human somatic cells. Epitalon restores pineal melatonin synthesis and circadian gene expression in aged organisms, increases BDNF, and upregulates CREB1. It also modulates the neuroendocrine system through its effects on the hypothalamic-pituitary axis and antioxidant enzyme regulation.
Standard: Research indicates 5-10 mg daily via subcutaneous injection for 10-20 day cycles.
Maintenance: Research indicates 10-day cycle of 5-10 mg daily, repeated every 4-6 months.
Administration: subcutaneousintramuscularintranasal
Timing: Evening administration preferred (aligns with pineal/melatonin function). Some protocols split doses AM/PM.
Duration: 10-20 day intensive cycles repeated every 4-6 months. Not used continuously.
Epitalon is the centerpiece of the anti-aging stack (Epitalon + GHK-Cu). Developed by Russian gerontologist Vladimir Khavinson over 25+ years of research. The cyclic dosing protocol (10-20 days every 4-6 months) is based on Khavinson's original research methodology. A 2025 study confirmed telomere elongation in human cell lines through both telomerase upregulation and ALT (alternative lengthening of telomeres) activity. The cancer concern with telomerase activation is theoretical but must be addressed with all clients. Improved sleep quality is the most commonly reported subjective effect.
Research-grade supplier with COA. Verify tetrapeptide sequence (AEDG). Store lyophilized at -20C.
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