Active metabolite of berberine with 5x greater absorption. AMPK activator that improves insulin sensitivity, reduces hepatic glucose production, and modulates gut microbiome. More bioavailable form allows lower dosing with fewer GI side effects.
Interactions
Same as berberine — CYP2D6/3A4/2C9 inhibitor
Potentiates metformin and other antidiabetics
May reduce efficacy of cyclosporine
Contraindications
Same as berberine — hypoglycemia risk with diabetic medications
Key Papers
Turner et al. 2008 - Berberine metabolites and glucose lowering (Metabolism)
Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.
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