Peptides
Evidence: moderate_human
Cerebrolysin is a porcine brain-derived peptide preparation containing a standardized mixture of low-molecular-weight neuropeptides (<10 kDa) and free amino acids obtained through enzymatic proteolysis. It exerts multimodal neurotrophic effects by simultaneously upregulating VEGF, BDNF, IGF-1, and NGF while downregulating TNF-alpha. Cerebrolysin increases furin protease concentration, which promotes pro-NGF to mature NGF conversion. It activates TrkB receptor signaling (BDNF/TrkB/CREB pathway), inhibits neuronal apoptosis, reduces microglial activation, and promotes neurogenesis.
Standard: Research indicates 10-30 mL daily via intravenous infusion for neurological indications. 5-10 mL for cognitive optimization.
Loading: Research indicates 20-30 mL daily IV for 10-20 days in acute neurological conditions (stroke, TBI).
Maintenance: Research indicates 5-10 mL daily or 3x weekly IV for cognitive maintenance.
Administration: intravenousintramuscular
Timing: Morning administration preferred for cognitive effects. IV infusion over 15-20 minutes.
Duration: 10-20 day intensive cycles repeated every 3-6 months. Some protocols use ongoing 3x weekly maintenance.
Cerebrolysin is approved in over 40 countries for neurological conditions including stroke recovery, traumatic brain injury, and various forms of dementia. It is one of the most extensively studied neuropeptide preparations with large-scale clinical trials. P21 was developed as a small-molecule alternative to capture Cerebrolysin's key neurotrophic effects in a BBB-permeable peptide. The IV administration requirement is a significant practical limitation. Cerebrolysin is porcine-derived — not suitable for clients with pork restrictions. Quality is well-controlled under pharmaceutical manufacturing standards.
Pharmaceutical-grade (manufactured by EVER Neuro Pharma). Approved in many countries for stroke, TBI, and dementia. Not FDA-approved in the US. Available through international pharmacies.
Take the free assessment and get personalized recommendations based on your biology and goals.
Get Your Free Protocolor take the assessment →