Urolithin A vs Wobenzym (Systemic Enzyme Complex)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Urolithin AWobenzym (Systemic Enzyme Complex)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongModerate
A

Urolithin A

Supplements

Mechanism

Gut metabolite of ellagitannins that activates mitophagy — selective clearance of damaged mitochondria. Improves mitochondrial function, muscle endurance, and cellular energy production. Only ~40% of population can produce it endogenously.

Contraindications

  • Limited long-term safety data beyond 4 months

Mechanism

Combination of bromelain, papain, trypsin, chymotrypsin, and pancreatin. Systemic enzyme therapy that degrades circulating immune complexes, reduces fibrin deposition, modulates cytokines (IL-6, TNF-alpha), and supports recovery from injury, surgery, and chronic inflammation.

Contraindications

  • Bleeding disorders
  • Pre-surgery
  • Severe liver or kidney disease

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