Sulforaphane (from Broccoli Sprout Extract) vs Wobenzym (Systemic Enzyme Complex)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Sulforaphane (from Broccoli Sprout Extract)Wobenzym (Systemic Enzyme Complex)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelStrongModerate

Mechanism

Isothiocyanate that activates Nrf2 — the master regulator of antioxidant defense. Upregulates glutathione synthesis, phase II detoxification enzymes, and heat shock proteins. Also inhibits HDAC (epigenetic modifier) and NF-kB (anti-inflammatory).

Contraindications

  • Thyroid conditions (goitrogen at very high doses)
  • Cruciferous vegetable allergy

Mechanism

Combination of bromelain, papain, trypsin, chymotrypsin, and pancreatin. Systemic enzyme therapy that degrades circulating immune complexes, reduces fibrin deposition, modulates cytokines (IL-6, TNF-alpha), and supports recovery from injury, surgery, and chronic inflammation.

Contraindications

  • Bleeding disorders
  • Pre-surgery
  • Severe liver or kidney disease

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