Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Sulforaphane (Broccoli Seed Extract) | Sulforaphane (from Broccoli Sprout Extract) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | 10-30mg sulforaphane daily (equivalent to ~100-200mg broccoli seed extract standardized to glucoraphanin + myrosinase) | — |
| Timing | On empty stomach or with light meal. Myrosinase enzyme required for conversion from glucoraphanin — ensure supplement contains it or add mustard seed powder. | — |
| Cycle Duration | ongoing | — |
| Evidence Level | strong_human | Strong |
Sulforaphane is the most potent natural activator of the Nrf2-ARE (antioxidant response element) pathway. It modifies Keap1 cysteine residues, releasing Nrf2 to translocate to the nucleus and upregulate >200 cytoprotective genes including NQO1, glutathione S-transferases, heme oxygenase-1, and UDP-glucuronosyltransferases (Phase II detox enzymes). It also inhibits HDAC activity (epigenetic modification), induces Phase II/III xenobiotic metabolism, and suppresses NF-kB inflammatory signaling.
10-30mg sulforaphane daily (equivalent to ~100-200mg broccoli seed extract standardized to glucoraphanin + myrosinase)
On empty stomach or with light meal. Myrosinase enzyme required for conversion from glucoraphanin — ensure supplement contains it or add mustard seed powder.
ongoing
Isothiocyanate that activates Nrf2 — the master regulator of antioxidant defense. Upregulates glutathione synthesis, phase II detoxification enzymes, and heat shock proteins. Also inhibits HDAC (epigenetic modifier) and NF-kB (anti-inflammatory).
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