Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Resveratrol | TUDCA | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | 250-500mg trans-resveratrol daily | — |
| Timing | Morning with a fat-containing meal. Often taken alongside NMN for synergistic sirtuin activation. | — |
| Cycle Duration | ongoing | — |
| Evidence Level | moderate_human | Moderate |
Resveratrol activates SIRT1 (the longevity sirtuin) via allosteric binding, promoting deacetylation of PGC-1alpha (mitochondrial biogenesis), FOXO3 (stress resistance), and p53 (DNA repair). It inhibits NF-kB and COX-2, reducing chronic inflammation. Resveratrol also activates AMPK independently of SIRT1 and inhibits phosphodiesterases (PDEs), raising cAMP levels. It improves endothelial function via eNOS upregulation and NO production.
250-500mg trans-resveratrol daily
Morning with a fat-containing meal. Often taken alongside NMN for synergistic sirtuin activation.
ongoing
Hydrophilic bile acid that stabilizes hepatocyte membranes, supports bile flow, and reduces endoplasmic reticulum stress. Often used in higher-load liver support and lipid-heavy protocols.
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