Resveratrol vs Serrapeptase

Mechanism

Resveratrol activates SIRT1 (the longevity sirtuin) via allosteric binding, promoting deacetylation of PGC-1alpha (mitochondrial biogenesis), FOXO3 (stress resistance), and p53 (DNA repair). It inhibits NF-kB and COX-2, reducing chronic inflammation. Resveratrol also activates AMPK independently of SIRT1 and inhibits phosphodiesterases (PDEs), raising cAMP levels. It improves endothelial function via eNOS upregulation and NO production.

Standard Dosing

250-500mg trans-resveratrol daily

Timing

Morning with a fat-containing meal. Often taken alongside NMN for synergistic sirtuin activation.

Cycle Duration

ongoing

Side Effects

• GI upset/diarrhea at high doses
• Headache
• Joint pain (rare)
• Insomnia (if taken late)

Contraindications

• Estrogen-sensitive cancers (theoretical ER agonism)
• Bleeding disorders
• Pregnancy/lactation

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Mechanism

Serrapeptase (serratiopeptidase) is a proteolytic enzyme originally isolated from the gut of the silkworm (Serratia marcescens). It hydrolyzes non-living tissue including fibrin, blood clots, cysts, and arterial plaque while sparing living tissue. It reduces bradykinin and other pain-mediating amines, provides anti-inflammatory effects by reducing neutrophil infiltration, and thins mucus by cleaving glycoprotein structures. It may also enhance antibiotic penetration into biofilms.

Standard Dosing

120,000-240,000 SPU (serratiopeptidase units) daily

Timing

On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after.

Cycle Duration

Cycle 4-8 weeks on, 2-4 weeks off

Side Effects

• GI discomfort
• Nausea
• Skin rash (rare)
• Muscle/joint pain (rare)
• Pneumonitis (very rare, case reports)

Contraindications

• Bleeding disorders
• Scheduled surgery (discontinue 2 weeks prior)
• Concurrent anticoagulant therapy
• Active peptic ulcers
• Active bleeding
• Pre-surgery
• Blood clotting disorders

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