R-Alpha Lipoic Acid vs Urolithin A

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

R-Alpha Lipoic AcidUrolithin A
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerateModerate-Strong

Mechanism

Redox-active cofactor that supports mitochondrial dehydrogenase complexes, glutathione recycling, and glucose disposal.

Contraindications

  • Monitor in clients prone to hypoglycemia
B

Urolithin A

Supplements

Mechanism

Gut metabolite of ellagitannins that activates mitophagy — selective clearance of damaged mitochondria. Improves mitochondrial function, muscle endurance, and cellular energy production. Only ~40% of population can produce it endogenously.

Contraindications

  • Limited long-term safety data beyond 4 months

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