Pterostilbene vs Pyrroloquinoline Quinone (PQQ)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

PterostilbenePyrroloquinoline Quinone (PQQ)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerateModerate
A

Pterostilbene

Supplements

Mechanism

Dimethylated analog of resveratrol with 4x greater oral bioavailability. Activates SIRT1 and AMPK, reduces oxidative stress, and improves lipid profiles. Superior pharmacokinetics compared to resveratrol due to methyl groups protecting against glucuronidation.

Contraindications

  • Hormone-sensitive conditions (mild estrogenic activity)

Mechanism

Redox cofactor that stimulates mitochondrial biogenesis via PGC-1alpha activation. Potent antioxidant (5000x more efficient than vitamin C in redox cycling). Supports nerve growth factor (NGF) synthesis and protects neurons from oxidative damage.

Contraindications

  • None established at standard doses

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