Phosphatidylserine (PS) vs Pterostilbene

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Phosphatidylserine (PS)Pterostilbene
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongModerate

Mechanism

Phospholipid concentrated in brain cell membranes. Supports neurotransmitter production (acetylcholine, dopamine), cortisol regulation, and membrane fluidity. Improves cognitive function, reduces exercise-induced cortisol, and supports HPA axis recovery.

Contraindications

  • Soy allergy (if soy-derived — use sunflower-derived instead)
B

Pterostilbene

Supplements

Mechanism

Dimethylated analog of resveratrol with 4x greater oral bioavailability. Activates SIRT1 and AMPK, reduces oxidative stress, and improves lipid profiles. Superior pharmacokinetics compared to resveratrol due to methyl groups protecting against glucuronidation.

Contraindications

  • Hormone-sensitive conditions (mild estrogenic activity)

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