Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| NR (Nicotinamide Riboside) | TUDCA | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | 300-600mg daily | — |
| Timing | Morning with or without food. | — |
| Cycle Duration | ongoing | — |
| Evidence Level | Moderate-Strong | Moderate |
NR is converted to NMN by nicotinamide riboside kinases (NRK1/NRK2), then to NAD+ via the salvage pathway. Like NMN, elevated NAD+ activates sirtuins, PARPs, and CD38. NR has demonstrated ability to cross the blood-brain barrier and elevate brain NAD+ levels. It supports mitochondrial function, DNA repair, and circadian rhythm regulation through SIRT1-mediated deacetylation of BMAL1 and CLOCK proteins.
300-600mg daily
Morning with or without food.
ongoing
Hydrophilic bile acid that stabilizes hepatocyte membranes, supports bile flow, and reduces endoplasmic reticulum stress. Often used in higher-load liver support and lipid-heavy protocols.
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