Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Inositol (Myo-Inositol + D-Chiro-Inositol) | Omega-3 (EPA/DHA) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive) |
| Timing | — | With meals containing fat for absorption. Split dose AM/PM. |
| Cycle Duration | — | ongoing |
| Evidence Level | Strong (PCOS, anxiety), Moderate (general metabolic) | strong_human |
Secondary messenger in insulin signaling cascade. Myo-inositol improves insulin sensitivity, reduces anxiety (via serotonin receptor modulation), and supports ovarian function. D-chiro-inositol complements by activating glycogen synthesis. 40:1 ratio mimics physiological balance.
EPA and DHA incorporate into cell membrane phospholipids, modulating membrane fluidity and lipid raft signaling. EPA competitively inhibits arachidonic acid conversion via COX-2 and 5-LOX, reducing pro-inflammatory eicosanoids (PGE2, LTB4) while generating anti-inflammatory resolvins and protectins. DHA is critical for neuronal membrane integrity, modulating BDNF expression and synaptic plasticity via Nrf2 and NF-kB pathways.
2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive)
With meals containing fat for absorption. Split dose AM/PM.
ongoing
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