Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Glycine + NAC (GlyNAC) | Inositol (Myo-Inositol + D-Chiro-Inositol) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Strong | Strong (PCOS, anxiety), Moderate (general metabolic) |
Combination that restores glutathione synthesis. Age-related glutathione deficiency is driven by glycine and cysteine precursor depletion, not enzyme dysfunction. GlyNAC corrects oxidative stress, mitochondrial dysfunction, inflammation, and insulin resistance in older adults.
Secondary messenger in insulin signaling cascade. Myo-inositol improves insulin sensitivity, reduces anxiety (via serotonin receptor modulation), and supports ovarian function. D-chiro-inositol complements by activating glycogen synthesis. 40:1 ratio mimics physiological balance.
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