Glycine + NAC (GlyNAC) vs HMB

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Glycine + NAC (GlyNAC)HMB
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelStrongModerate

Mechanism

Combination that restores glutathione synthesis. Age-related glutathione deficiency is driven by glycine and cysteine precursor depletion, not enzyme dysfunction. GlyNAC corrects oxidative stress, mitochondrial dysfunction, inflammation, and insulin resistance in older adults.

Contraindications

  • Active stomach ulcer (NAC)
  • Asthma (NAC may cause bronchospasm in rare cases)
B

HMB

Supplements

Mechanism

Leucine metabolite that reduces muscle protein breakdown and may support recovery under high training or caloric deficit conditions.

Contraindications

  • None established at standard doses

Not sure which is right for you?

Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.

Get Your Free Protocol →or take the assessment →