Glucoraphanin (Broccoli Seed Extract) vs Pentadecanoic Acid (C15:0 / Fatty15)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Glucoraphanin (Broccoli Seed Extract)Pentadecanoic Acid (C15:0 / Fatty15)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongEmerging

Mechanism

Stable precursor to sulforaphane. Requires myrosinase enzyme (from gut bacteria or co-administered) for conversion. Provides sustained sulforaphane release compared to direct supplementation. Activates Nrf2 pathway for antioxidant and detoxification gene expression.

Contraindications

  • Thyroid conditions (goitrogen at very high doses)

Mechanism

Odd-chain saturated fatty acid identified as essential. Strengthens cell membranes by integrating into phospholipid bilayer, activates AMPK and PPAR-alpha/delta, and inhibits mTOR. Repairs mitochondrial function. Epidemiologically associated with reduced cardiometabolic disease.

Contraindications

  • None established

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