Diosmin + Hesperidin vs Quercetin

Mechanism

Micronized flavonoid fraction that strengthens venous tone, reduces capillary permeability, and improves lymphatic drainage. Inhibits prostaglandin and thromboxane synthesis. Used as prescription venotonic in Europe for chronic venous insufficiency and hemorrhoids.

Contraindications

• None established at standard doses

Mechanism

Quercetin is a flavonoid that inhibits mast cell degranulation and histamine release, functions as a potent senolytic (selectively clearing senescent cells) when combined with dasatinib or fisetin, and activates AMPK and SIRT1 pathways. It inhibits PI3K/Akt/mTOR signaling, suppresses NF-kB, and modulates JAK-STAT inflammatory cascades. As a zinc ionophore, it facilitates zinc entry into cells, which may inhibit viral RNA-dependent RNA polymerase.

Standard Dosing

500-1000mg daily

Timing

With meals for absorption. For senolytic effect: 3-day pulse monthly on empty stomach.

Cycle Duration

ongoing for general use; pulsed monthly for senolytic protocols

Side Effects

• Headache
• Mild GI upset
• Tingling extremities at high doses
• Rare: kidney toxicity at very high doses

Contraindications

• Pregnancy/lactation at high doses
• Concurrent cyclosporine therapy

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