Citrus Bergamot Extract vs R-Alpha Lipoic Acid

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Citrus Bergamot ExtractR-Alpha Lipoic Acid
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongModerate

Mechanism

Contains brutieridin and melitidin — statin-like HMG-CoA reductase inhibitors from bergamot orange. Activates AMPK, improves lipid profiles (reduces LDL, increases HDL), and has antioxidant effects. Supports cardiovascular and metabolic health.

Contraindications

  • Rhabdomyolysis risk if combined with high-dose statins without monitoring

Mechanism

Redox-active cofactor that supports mitochondrial dehydrogenase complexes, glutathione recycling, and glucose disposal.

Contraindications

  • Monitor in clients prone to hypoglycemia

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