Citrus Bergamot Extract vs Quercetin

Mechanism

Contains brutieridin and melitidin — statin-like HMG-CoA reductase inhibitors from bergamot orange. Activates AMPK, improves lipid profiles (reduces LDL, increases HDL), and has antioxidant effects. Supports cardiovascular and metabolic health.

Contraindications

• Rhabdomyolysis risk if combined with high-dose statins without monitoring

Mechanism

Quercetin is a flavonoid that inhibits mast cell degranulation and histamine release, functions as a potent senolytic (selectively clearing senescent cells) when combined with dasatinib or fisetin, and activates AMPK and SIRT1 pathways. It inhibits PI3K/Akt/mTOR signaling, suppresses NF-kB, and modulates JAK-STAT inflammatory cascades. As a zinc ionophore, it facilitates zinc entry into cells, which may inhibit viral RNA-dependent RNA polymerase.

Standard Dosing

500-1000mg daily

Timing

With meals for absorption. For senolytic effect: 3-day pulse monthly on empty stomach.

Cycle Duration

ongoing for general use; pulsed monthly for senolytic protocols

Side Effects

• Headache
• Mild GI upset
• Tingling extremities at high doses
• Rare: kidney toxicity at very high doses

Contraindications

• Pregnancy/lactation at high doses
• Concurrent cyclosporine therapy

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