Citrus Bergamot Extract vs Pycnogenol

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Citrus Bergamot ExtractPycnogenol
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongModerate

Mechanism

Contains brutieridin and melitidin — statin-like HMG-CoA reductase inhibitors from bergamot orange. Activates AMPK, improves lipid profiles (reduces LDL, increases HDL), and has antioxidant effects. Supports cardiovascular and metabolic health.

Contraindications

  • Rhabdomyolysis risk if combined with high-dose statins without monitoring
B

Pycnogenol

Supplements

Mechanism

Polyphenol-rich French maritime pine bark extract that improves endothelial nitric oxide signaling, capillary tone, and oxidative defense.

Contraindications

  • Use caution before surgery

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