Citrus Bergamot Extract vs Phosphatidylserine (PS)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Citrus Bergamot ExtractPhosphatidylserine (PS)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongModerate-Strong

Mechanism

Contains brutieridin and melitidin — statin-like HMG-CoA reductase inhibitors from bergamot orange. Activates AMPK, improves lipid profiles (reduces LDL, increases HDL), and has antioxidant effects. Supports cardiovascular and metabolic health.

Contraindications

  • Rhabdomyolysis risk if combined with high-dose statins without monitoring

Mechanism

Phospholipid concentrated in brain cell membranes. Supports neurotransmitter production (acetylcholine, dopamine), cortisol regulation, and membrane fluidity. Improves cognitive function, reduces exercise-induced cortisol, and supports HPA axis recovery.

Contraindications

  • Soy allergy (if soy-derived — use sunflower-derived instead)

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