Citrus Bergamot Extract vs HMB

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Citrus Bergamot ExtractHMB
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongModerate

Mechanism

Contains brutieridin and melitidin — statin-like HMG-CoA reductase inhibitors from bergamot orange. Activates AMPK, improves lipid profiles (reduces LDL, increases HDL), and has antioxidant effects. Supports cardiovascular and metabolic health.

Contraindications

  • Rhabdomyolysis risk if combined with high-dose statins without monitoring
B

HMB

Supplements

Mechanism

Leucine metabolite that reduces muscle protein breakdown and may support recovery under high training or caloric deficit conditions.

Contraindications

  • None established at standard doses

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