Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Calcium Alpha-Ketoglutarate (Ca-AKG) | PQQ (Pyrroloquinoline Quinone) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 10-20mg daily |
| Timing | — | With breakfast. Can combine in same meal with CoQ10. |
| Cycle Duration | — | ongoing |
| Evidence Level | Moderate (healthspan), Emerging (human longevity) | moderate_human |
AKG is a TCA cycle intermediate that declines with age. Supplementation reduces inflammatory cytokines, improves stem cell function, and extends healthspan in mice. Calcium salt form provides sustained release. Also supports collagen synthesis and reduces frailty markers.
PQQ activates PGC-1alpha via CREB phosphorylation, directly stimulating mitochondrial biogenesis — the formation of new mitochondria. It acts as a redox cycling agent capable of thousands of catalytic oxidation-reduction cycles (compared to ~4 for vitamin C), providing exceptional antioxidant capacity. PQQ also modulates NMDA receptor signaling and promotes nerve growth factor (NGF) synthesis, supporting neuronal health and cognitive function.
10-20mg daily
With breakfast. Can combine in same meal with CoQ10.
ongoing
Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.
Get Your Free Protocol →or take the assessment →