Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Calcium Alpha-Ketoglutarate (Ca-AKG) | Pentadecanoic Acid (C15:0 / Fatty15) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Moderate (healthspan), Emerging (human longevity) | Emerging |
AKG is a TCA cycle intermediate that declines with age. Supplementation reduces inflammatory cytokines, improves stem cell function, and extends healthspan in mice. Calcium salt form provides sustained release. Also supports collagen synthesis and reduces frailty markers.
Odd-chain saturated fatty acid identified as essential. Strengthens cell membranes by integrating into phospholipid bilayer, activates AMPK and PPAR-alpha/delta, and inhibits mTOR. Repairs mitochondrial function. Epidemiologically associated with reduced cardiometabolic disease.
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