Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Calcium Alpha-Ketoglutarate (Ca-AKG) | NR (Nicotinamide Riboside) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 300-600mg daily |
| Timing | — | Morning with or without food. |
| Cycle Duration | — | ongoing |
| Evidence Level | Moderate (healthspan), Emerging (human longevity) | Moderate-Strong |
AKG is a TCA cycle intermediate that declines with age. Supplementation reduces inflammatory cytokines, improves stem cell function, and extends healthspan in mice. Calcium salt form provides sustained release. Also supports collagen synthesis and reduces frailty markers.
NR is converted to NMN by nicotinamide riboside kinases (NRK1/NRK2), then to NAD+ via the salvage pathway. Like NMN, elevated NAD+ activates sirtuins, PARPs, and CD38. NR has demonstrated ability to cross the blood-brain barrier and elevate brain NAD+ levels. It supports mitochondrial function, DNA repair, and circadian rhythm regulation through SIRT1-mediated deacetylation of BMAL1 and CLOCK proteins.
300-600mg daily
Morning with or without food.
ongoing
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