Bromelain vs Pycnogenol

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

BromelainPycnogenol
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerateModerate
A

Bromelain

Supplements

Mechanism

Proteolytic enzyme complex from pineapple stems. Anti-inflammatory via modulation of prostaglandin synthesis, fibrinolytic, and anti-edematous. Degrades fibrin and reduces blood viscosity. Enhances absorption of other supplements (particularly quercetin and curcumin).

Contraindications

  • Pineapple allergy
  • Pre-surgery (bleeding risk)
  • Active bleeding
B

Pycnogenol

Supplements

Mechanism

Polyphenol-rich French maritime pine bark extract that improves endothelial nitric oxide signaling, capillary tone, and oxidative defense.

Contraindications

  • Use caution before surgery

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