Bromelain vs PQQ (Pyrroloquinoline Quinone)

Mechanism

Proteolytic enzyme complex from pineapple stems. Anti-inflammatory via modulation of prostaglandin synthesis, fibrinolytic, and anti-edematous. Degrades fibrin and reduces blood viscosity. Enhances absorption of other supplements (particularly quercetin and curcumin).

Contraindications

• Pineapple allergy
• Pre-surgery (bleeding risk)
• Active bleeding

Mechanism

PQQ activates PGC-1alpha via CREB phosphorylation, directly stimulating mitochondrial biogenesis — the formation of new mitochondria. It acts as a redox cycling agent capable of thousands of catalytic oxidation-reduction cycles (compared to ~4 for vitamin C), providing exceptional antioxidant capacity. PQQ also modulates NMDA receptor signaling and promotes nerve growth factor (NGF) synthesis, supporting neuronal health and cognitive function.

Standard Dosing

10-20mg daily

Timing

With breakfast. Can combine in same meal with CoQ10.

Cycle Duration

ongoing

Side Effects

• Rare: headache
• Mild GI discomfort at higher doses
• Insomnia if taken late

Contraindications

• Pregnancy/lactation (insufficient safety data)

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