Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Sulforaphane (Broccoli Seed Extract) | Wobenzym (Systemic Enzyme Complex) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | 10-30mg sulforaphane daily (equivalent to ~100-200mg broccoli seed extract standardized to glucoraphanin + myrosinase) | — |
| Timing | On empty stomach or with light meal. Myrosinase enzyme required for conversion from glucoraphanin — ensure supplement contains it or add mustard seed powder. | — |
| Cycle Duration | ongoing | — |
| Evidence Level | strong_human | Moderate |
Sulforaphane is the most potent natural activator of the Nrf2-ARE (antioxidant response element) pathway. It modifies Keap1 cysteine residues, releasing Nrf2 to translocate to the nucleus and upregulate >200 cytoprotective genes including NQO1, glutathione S-transferases, heme oxygenase-1, and UDP-glucuronosyltransferases (Phase II detox enzymes). It also inhibits HDAC activity (epigenetic modification), induces Phase II/III xenobiotic metabolism, and suppresses NF-kB inflammatory signaling.
10-30mg sulforaphane daily (equivalent to ~100-200mg broccoli seed extract standardized to glucoraphanin + myrosinase)
On empty stomach or with light meal. Myrosinase enzyme required for conversion from glucoraphanin — ensure supplement contains it or add mustard seed powder.
ongoing
Combination of bromelain, papain, trypsin, chymotrypsin, and pancreatin. Systemic enzyme therapy that degrades circulating immune complexes, reduces fibrin deposition, modulates cytokines (IL-6, TNF-alpha), and supports recovery from injury, surgery, and chronic inflammation.
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