Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Retatrutide | Tesofensine | |
|---|---|---|
| Category | Pharmaceuticals | Pharmaceuticals |
| Standard Dose | — | Research indicates 0.25-0.5 mg daily via oral administration. |
| Timing | — | Morning dosing only. Avoid afternoon/evening dosing due to stimulant properties and potential insomnia. |
| Cycle Duration | — | 12-24 week cycles. Monitor cardiovascular parameters throughout. |
| Evidence Level | Emerging (Phase 3 ongoing) | moderate_human |
Triple incretin agonist (GIP/GLP-1/glucagon receptor). Combines appetite suppression and insulin sensitization of GLP-1 with the thermogenic and lipolytic effects of glucagon receptor activation. Produced the greatest weight loss of any anti-obesity agent in Phase 2 trials (~24% at 48 weeks).
Tesofensine (NS2330) is a triple monoamine reuptake inhibitor with affinity for dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters. It suppresses appetite through indirect stimulation of alpha-1 adrenoceptor and dopamine D1 receptor pathways, reflecting additive effects of increased NE and DA activity. Tesofensine is a dual-action drug with both anorexigenic properties (appetite suppression) and metabolic properties (increased energy expenditure), silencing GABAergic hypothalamic neurons in the lateral hypothalamus.
Research indicates 0.25-0.5 mg daily via oral administration.
Morning dosing only. Avoid afternoon/evening dosing due to stimulant properties and potential insomnia.
12-24 week cycles. Monitor cardiovascular parameters throughout.
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