Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Resveratrol | Wobenzym (Systemic Enzyme Complex) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | 250-500mg trans-resveratrol daily | — |
| Timing | Morning with a fat-containing meal. Often taken alongside NMN for synergistic sirtuin activation. | — |
| Cycle Duration | ongoing | — |
| Evidence Level | moderate_human | Moderate |
Resveratrol activates SIRT1 (the longevity sirtuin) via allosteric binding, promoting deacetylation of PGC-1alpha (mitochondrial biogenesis), FOXO3 (stress resistance), and p53 (DNA repair). It inhibits NF-kB and COX-2, reducing chronic inflammation. Resveratrol also activates AMPK independently of SIRT1 and inhibits phosphodiesterases (PDEs), raising cAMP levels. It improves endothelial function via eNOS upregulation and NO production.
250-500mg trans-resveratrol daily
Morning with a fat-containing meal. Often taken alongside NMN for synergistic sirtuin activation.
ongoing
Combination of bromelain, papain, trypsin, chymotrypsin, and pancreatin. Systemic enzyme therapy that degrades circulating immune complexes, reduces fibrin deposition, modulates cytokines (IL-6, TNF-alpha), and supports recovery from injury, surgery, and chronic inflammation.
Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.
Get Your Free Protocol →or take the assessment →