Pycnogenol vs Wobenzym (Systemic Enzyme Complex)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

PycnogenolWobenzym (Systemic Enzyme Complex)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerateModerate
A

Pycnogenol

Supplements

Mechanism

Polyphenol-rich French maritime pine bark extract that improves endothelial nitric oxide signaling, capillary tone, and oxidative defense.

Contraindications

  • Use caution before surgery

Mechanism

Combination of bromelain, papain, trypsin, chymotrypsin, and pancreatin. Systemic enzyme therapy that degrades circulating immune complexes, reduces fibrin deposition, modulates cytokines (IL-6, TNF-alpha), and supports recovery from injury, surgery, and chronic inflammation.

Contraindications

  • Bleeding disorders
  • Pre-surgery
  • Severe liver or kidney disease

Not sure which is right for you?

Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.

Get Your Free Protocol →or take the assessment →