PQQ vs Resveratrol

Mechanism

Redox-active quinone that supports mitochondrial biogenesis signaling and resilience under oxidative load.

Contraindications

• Limited long-term human safety data

Mechanism

Resveratrol activates SIRT1 (the longevity sirtuin) via allosteric binding, promoting deacetylation of PGC-1alpha (mitochondrial biogenesis), FOXO3 (stress resistance), and p53 (DNA repair). It inhibits NF-kB and COX-2, reducing chronic inflammation. Resveratrol also activates AMPK independently of SIRT1 and inhibits phosphodiesterases (PDEs), raising cAMP levels. It improves endothelial function via eNOS upregulation and NO production.

Standard Dosing

250-500mg trans-resveratrol daily

Timing

Morning with a fat-containing meal. Often taken alongside NMN for synergistic sirtuin activation.

Cycle Duration

ongoing

Side Effects

• GI upset/diarrhea at high doses
• Headache
• Joint pain (rare)
• Insomnia (if taken late)

Contraindications

• Estrogen-sensitive cancers (theoretical ER agonism)
• Bleeding disorders
• Pregnancy/lactation

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