Phosphatidylserine (PS) vs R-Alpha Lipoic Acid

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Phosphatidylserine (PS)R-Alpha Lipoic Acid
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongModerate

Mechanism

Phospholipid concentrated in brain cell membranes. Supports neurotransmitter production (acetylcholine, dopamine), cortisol regulation, and membrane fluidity. Improves cognitive function, reduces exercise-induced cortisol, and supports HPA axis recovery.

Contraindications

  • Soy allergy (if soy-derived — use sunflower-derived instead)

Mechanism

Redox-active cofactor that supports mitochondrial dehydrogenase complexes, glutathione recycling, and glucose disposal.

Contraindications

  • Monitor in clients prone to hypoglycemia

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