Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Palmitoylethanolamide (PEA) | R-Alpha Lipoic Acid | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Strong | Moderate |
Endocannabinoid-like lipid that activates PPAR-alpha and indirectly enhances endocannabinoid tone. Potent anti-inflammatory and analgesic without acting directly on CB1/CB2. Reduces mast cell activation, neuroinflammation, and chronic pain.
Redox-active cofactor that supports mitochondrial dehydrogenase complexes, glutathione recycling, and glucose disposal.
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