Luteolin vs Pycnogenol

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

LuteolinPycnogenol
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelEmergingModerate
A

Luteolin

Supplements

Mechanism

Flavone that modulates mast-cell activation, microglial signaling, and inflammatory cascades including NF-kB activity.

Contraindications

  • Limited pregnancy data
B

Pycnogenol

Supplements

Mechanism

Polyphenol-rich French maritime pine bark extract that improves endothelial nitric oxide signaling, capillary tone, and oxidative defense.

Contraindications

  • Use caution before surgery

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