Low-Dose Naltrexone vs Retatrutide

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Low-Dose NaltrexoneRetatrutide
CategoryPharmaceuticalsPharmaceuticals
Standard Dose——
Timing——
Cycle Duration——
Evidence LevelEmergingEmerging (Phase 3 ongoing)
A

Low-Dose Naltrexone

Pharmaceuticals

Mechanism

Transient opioid receptor blockade that may increase endogenous endorphin signaling and modulate immune tone in off-label protocols.

Contraindications

  • Concurrent opioid use
  • Use caution in active liver disease
B

Retatrutide

Pharmaceuticals

Mechanism

Triple incretin agonist (GIP/GLP-1/glucagon receptor). Combines appetite suppression and insulin sensitization of GLP-1 with the thermogenic and lipolytic effects of glucagon receptor activation. Produced the greatest weight loss of any anti-obesity agent in Phase 2 trials (~24% at 48 weeks).

Contraindications

  • Not FDA-approved
  • Presumed similar to GLP-1 class — MTC, pancreatitis, severe GI disease

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