Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Inositol (Myo-Inositol + D-Chiro-Inositol) | Quercetin | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 500-1000mg daily |
| Timing | — | With meals for absorption. For senolytic effect: 3-day pulse monthly on empty stomach. |
| Cycle Duration | — | ongoing for general use; pulsed monthly for senolytic protocols |
| Evidence Level | Strong (PCOS, anxiety), Moderate (general metabolic) | moderate_human |
Secondary messenger in insulin signaling cascade. Myo-inositol improves insulin sensitivity, reduces anxiety (via serotonin receptor modulation), and supports ovarian function. D-chiro-inositol complements by activating glycogen synthesis. 40:1 ratio mimics physiological balance.
Quercetin is a flavonoid that inhibits mast cell degranulation and histamine release, functions as a potent senolytic (selectively clearing senescent cells) when combined with dasatinib or fisetin, and activates AMPK and SIRT1 pathways. It inhibits PI3K/Akt/mTOR signaling, suppresses NF-kB, and modulates JAK-STAT inflammatory cascades. As a zinc ionophore, it facilitates zinc entry into cells, which may inhibit viral RNA-dependent RNA polymerase.
500-1000mg daily
With meals for absorption. For senolytic effect: 3-day pulse monthly on empty stomach.
ongoing for general use; pulsed monthly for senolytic protocols
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