Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Human Chorionic Gonadotropin (hCG) | Kisspeptin-10 | |
|---|---|---|
| Category | Hormones | Peptides |
| Standard Dose | — | Research indicates 1-10 mcg/kg via subcutaneous injection or IV bolus for acute HPG axis stimulation. |
| Timing | — | Morning dosing preferred for testosterone optimization. Can be used acutely before sexual activity. |
| Cycle Duration | — | Short-term use only. Continuous kisspeptin administration may cause tachyphylaxis (desensitization) of the HPG axis. |
| Evidence Level | Strong | moderate_human |
LH receptor agonist that stimulates intratesticular testosterone production and can help preserve fertility signaling in selected male hormone protocols.
Kisspeptin-10 is the 10-amino acid C-terminal fragment of the kisspeptin family that signals directly to GnRH neurons through the kisspeptin receptor (KISS1R/GPR54), triggering GnRH release into the portal circulation. This stimulates LH and FSH secretion from anterior pituitary gonadotrophs. In men, intravenous kisspeptin-10 produces rapid dose-dependent LH rises (4.1 to 12.4 IU/L at 1 mcg/kg within 30 minutes), increases LH pulse frequency and amplitude, and subsequently elevates testosterone through the HPG axis.
Research indicates 1-10 mcg/kg via subcutaneous injection or IV bolus for acute HPG axis stimulation.
Morning dosing preferred for testosterone optimization. Can be used acutely before sexual activity.
Short-term use only. Continuous kisspeptin administration may cause tachyphylaxis (desensitization) of the HPG axis.
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