HMB vs Phosphatidylserine (PS)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

HMBPhosphatidylserine (PS)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerateModerate-Strong
A

HMB

Supplements

Mechanism

Leucine metabolite that reduces muscle protein breakdown and may support recovery under high training or caloric deficit conditions.

Contraindications

  • None established at standard doses

Mechanism

Phospholipid concentrated in brain cell membranes. Supports neurotransmitter production (acetylcholine, dopamine), cortisol regulation, and membrane fluidity. Improves cognitive function, reduces exercise-induced cortisol, and supports HPA axis recovery.

Contraindications

  • Soy allergy (if soy-derived — use sunflower-derived instead)

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