Gotu Kola (Centella asiatica) vs Sabroxy (Oroxylum indicum)

Mechanism

Pentacyclic triterpenes — asiaticoside, madecassoside, asiatic acid, and madecassic acid — provide neuroprotection through multiple mechanisms: inhibition of acetylcholinesterase activity and enhancement of cholinergic transmission; reduction of phospholipase A2 (PLA2) activity to attenuate neuroinflammation; protection against beta-amyloid aggregation and tau hyperphosphorylation; and upregulation of BDNF to promote neuronal growth and synaptic plasticity. Asiaticoside enhances collagen synthesis and wound healing, while asiatic acid activates the MAPK/ERK pathway to promote neurite outgrowth.

Standard Dosing

500-1000 mg/day of standardized extract (35-45% triterpenes) or 750-1500 mg/day of whole herb extract

Timing

Morning or split morning/afternoon. With or without food. Acute mood effects (alertness, reduced anger) noted within 1 hour of dosing.

Cycle Duration

Ongoing; traditional use suggests no cycling required. Clinical trials run 2-6 months.

Side Effects

• GI discomfort
• Drowsiness
• Headache
• Skin irritation (topical use)
• Hepatotoxicity (rare, with prolonged high-dose use)

Contraindications

• Pregnancy (traditionally contraindicated; may have emmenagogue effects)
• Hepatic disease (rare hepatotoxicity reported)
• Scheduled surgery (may affect wound healing dynamics)

Best Stacking Partners

Mechanism

Contains oroxylin A — a flavonoid that inhibits PDE (phosphodiesterase), increases BDNF, and modulates dopamine signaling. Enhances focus and motivation without stimulant side effects. Also acts as a mild MAO-B inhibitor, preserving dopamine levels.

Contraindications

• Concurrent MAO inhibitors