Cetyl Myristoleate (CMO) vs Tributyrin (Butyrate Prodrug)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Cetyl Myristoleate (CMO)Tributyrin (Butyrate Prodrug)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelLimited-ModerateModerate

Mechanism

Fatty acid ester with anti-inflammatory and joint-lubricating properties. Modulates immune response by inhibiting 5-lipoxygenase and modulating prostaglandin synthesis. Reduces joint inflammation and improves range of motion in arthritic conditions.

Contraindications

  • Severe liver disease

Mechanism

Tributyrin is a triglyceride form of butyrate — a short-chain fatty acid critical for colonocyte health. HDAC inhibitor that supports gut barrier integrity, reduces intestinal inflammation, and modulates immune function. Superior absorption compared to sodium butyrate.

Contraindications

  • None established at standard doses

Not sure which is right for you?

Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.

Get Your Free Protocol →or take the assessment →